Dilatation and curettage (D&C), as the traditional gold standard procedure for diagnosing endometrial cancer, is painful, expensive, requires general anesthesia and has a high rate of misdiagnosis ( 2). So we recommend that D&C and Pipelle are still practical procedures to evaluate the endometrium, cytological examinations should be utilized as an additional endometrial assessment method.Įndometrial cancer is becoming the primary reason of female deaths of genital track cancer in developed countries ( 1). The diagnostic odds ratio which was usually used to evaluate the diagnostic test performance reached 260 (95% CI 36–1905). The pooled positive likelihood ratio and negative likelihood ratio was 25.4 (95% CI 8.1–80.1) and 0.10 (95% CI 0.00–0.30), respectively. The pooled sensitivity and specificity of the cytological method in detecting endometrial atypical hyperplasia or cancer was 0.91 and 0.96 (95% CI 0.90–0.99), respectively. Following that, a meta-analysis including 4,179 patients of endometrial diseases with cyto-histopathological results was performed to assess the value of the endometrial cytological method in endometrial cancer diagnosis. We report a case of misdiagnosed endometrial cancer by D&C, but with a positive cytopathological finding. Endometrial cytology is often compared with histology and seems to be an efficient method for the diagnosis of endometrial disorders, especially endometrial cancer. More and more researchers have reported that dilatation and curettage (D&C) or Pipelle had low accuracy, high misdiagnosis, and insufficient rate. ![]() 4Department of Pathology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.3Guipei 77, Health Science Center, Xi'an Jiaotong University, Xi'an, China.2Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.1Center for Single-Cell Biology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.Qing Wang 1,2 †, Qi Wang 1,2 †, Lanbo Zhao 3, Lu Han 1,2, Chao Sun 1,2, Sijia Ma 1,2, Huilian Hou 4, Qing Song 1 and Qiling Li 1,2 *
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